Pd-catalyzed borylative cyclisation of 1,7-enynes.
نویسندگان
چکیده
Reaction of a variety of 1,7-enynes with bis(pinacolato) diboron catalysed by Pd bis(trifluoroacetate) affords homoallylic and allylic boronates containing a six membered carbo- or heterocycle, by formation of C-C and C-B bonds.
منابع مشابه
Ligand-controlled divergent formation of alkenyl- or allylboronates catalyzed by Pd, and synthetic applications.
The use of different ligands allows the preparation of either allyl- or alkenylboronates by Pd-catalyzed borylation of allylic carbonates containing alkyne groups. Unprecedented borylative cyclisation to alkenylboronates takes place with PCy3. The difficult dissociation of NHC ligands allows borylation of carbonates in the presence of alkynes. Oxidation, regioselective Suzuki coupling, as well ...
متن کاملA borylative cyclisation towards indole boronic esters.
2-Alkynylaniline borylative cyclisations provide a direct means to access indole 3-boronic esters from simple precursors. The Pd-catalysed cyclisation can be merged with cross-coupling processes in the same reaction vessel, moreover, the products can be exploited in C-N bond forming reactions.
متن کاملGold-catalyzed diastereoselective [2+2+2]-cycloaddition of 1,7-enynes with carbonyl compounds.
We report a gold-catalyzed [2+2+2]-cycloaddition of 1,7-enynes with carbonyl species; our experimental data suggest that the resulting oxacyclic cycloadducts arose from an interception of gold-containing cyclobutenium intermediates with carbonyl species.
متن کاملPalladium-catalyzed enantioselective cyclization of silyloxy-1,6-enynes.
Transition-metal-catalyzed cycloisomerization and cyclization reactions of enynes have emerged as powerful methods for the construction of heteroand carbocyclic compounds.1 More recently, enantioselective cycloisomerization of 1,6and 1,7-enynes has been employed in the preparation of enantioenriched 1,4-diene containing structures.2-4 Despite its potential utility, the related enantioselective ...
متن کاملPreparation of allylboronates by Pd-catalysed borylative cyclisation of dienynes.
Reaction of a variety of dienynes with bis(pinacolato)diboron catalysed by Pd bis(trifluoroacetate) affords allylic boronates containing five or six membered carbo- or heterocycles, by concomitant formation of one C-C and one C-B bonds. Resulting allylboronates can be employed for a variety of subsequent transformations.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 48 85 شماره
صفحات -
تاریخ انتشار 2012